Tishchenko反应，两分子的醛通过歧化反应制备酯的反应。

反应机理

烷氧基铝作为 Lewis酸和一分子醛络合，络合得到的活化的羰基更容易被第二分子的醛进行加成，生成半缩醛中间体：

生成的半缩醛中间体通过分子内的1,3-氢迁移得到铝配位的酯。

此反应可能的副反应是催化剂的烷氧基参与下述历程：

可以通过降低反应温度和减少催化剂的量来减少此副反应的影响。

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编译自：Organic Chemistry Portal